The laboratory focuses upon the development and application of new neuroimaging and analysis methods to identify brain circuitry abnormalities underlying neuropsychiatric disorders. There is a particular emphasis on using translational fMRI probes with targeted analyses to test hypotheses concerning mechanisms of fronto-limbic-subcortical dysfunction leading to symptom formation. Because of the extensive overlap of aspects of symptomatology across many neuropsychiatric diseases, this circuitry is examined across disorders, to identify potential common biological substrates of symptom formation. It is our hope that this approach will lead to improved, biologically-based diagnostic and therapeutic approaches.